Actor and comedian Dave Coulier has revealed a new, unrelated cancer diagnosis — but remains optimistic thanks to early detection.

Dave Coulier, best known for his role as Uncle Joey on Full House, is opening up about another major health challenge. Only months after overcoming stage 3 non-Hodgkin lymphoma, the actor has now been diagnosed with p16 squamous carcinoma, a form of head and neck cancer. Coulier shared the news during a recent appearance on Today, explaining that the discovery came as a result of routine post-treatment scans.

A New Diagnosis — and It’s Unrelated to His Previous Cancer

Coulier said his doctors identified the cancer following an October PET scan. Although he initially wondered whether the new cancer was connected to his lymphoma, medical teams confirmed the two conditions were unrelated.

The actor explained that the carcinoma was found at the base of his tongue, and he is currently undergoing a series of 35 targeted radiation treatments, expected to be completed by December 31.

Despite the shock of another diagnosis, Coulier emphasized that the prognosis is strong.
“Prognosis is very good… there’s a 90+ percent curability rate,” he shared.

He added that early detection has repeatedly been a lifesaver for him and urged viewers to stay consistent with medical checkups, including screenings like colonoscopies, breast exams and prostate exams.

Turning His Experience Into Purpose

In addition to sharing his health journey, Coulier also discussed a new personal project. Inspired by his attempts to eliminate harmful chemicals from his home during chemotherapy, he created AwareMarket, a digital platform focused on toxin-free and holistic products.

The idea grew from his desire to build a healthier environment while navigating treatment — something he hopes can help others doing the same.

A Difficult Journey — and a Family History of Cancer

This is not the first time Coulier has confronted cancer. Alongside his own diagnoses, he has experienced profound loss within his family:

• His mother and sister Sharon both passed away from breast cancer.
• His niece died from the disease at age 29.
• His older sister Karen has also undergone cancer treatment.

These deeply personal experiences, Coulier says, have shaped how he approaches his own health battles.
“If I can be even a fraction as strong as they were, then I’m going to be just fine,” he said in a 2024 interview.

Sharing His Story to Inspire Others

Coulier has been candid about his medical challenges over the past year, from revealing his first diagnosis in 2024 to updating fans as he progressed through difficult rounds of chemotherapy. His openness, he explains, is meant to motivate others to take their health seriously.

He and his wife Melissa, whom he married in 2014, have been honest about how emotionally challenging chemo could be. Melissa shared that during one particularly hard moment, they even had difficult “what if” conversations. Still, the couple continued to support each other through recovery.

Today, Coulier hopes his story encourages people not to delay medical care.
“Take great care of yourself… screenings can make a big change in your life,” he said.