Ahead of a crucial stretch in the 2025 NFL season, Denver Broncos linebacker Alex Singleton was focused on leading one of the league’s top defensive units. But behind the scenes, a shocking medical discovery—triggered by what appeared to be a failed drug test—ended up saving his life.
Singleton, a 31-year-old defensive captain known for his relentless tackling and leadership, was performing at an elite level when a routine NFL drug screen unexpectedly revealed abnormal results. That test set off a chain of events that led to the early detection of testicular cancer, a diagnosis that could have ended his career if not caught in time.
A Routine Test Uncovers a Hidden Threat
On October 29, Singleton found a confidential letter waiting in his locker. The drug test sample he provided after Denver’s victory over the New York Jets had shown elevated levels of hCG, a hormone rarely found in men unless:
- It’s been injected artificially, or
- The body is fighting testicular cancer
Singleton was stunned. With no history of using banned substances, he immediately recognized the gravity of the situation.
He informed his wife, Sam, who had recently given birth to their daughter, and scheduled urgent medical appointments. At that moment, Singleton didn’t know if he was facing a cancer battle or an NFL suspension. Both possibilities weighed heavily on him as he continued to suit up for the Broncos.
Playing Through Fear and Uncertainty
The linebacker took the field against the Houston Texans the next day, all while wrestling with the terrifying unknown. He later admitted the diagnosis was on his mind throughout the game, yet he pushed forward—unwilling to let fear dictate his last memory on the field.
After confirming the cancer diagnosis, he refused to step away before Denver’s next game. For Singleton, the threat of losing football—his lifelong passion—was almost harder to process than the disease itself.
“My biggest fear was the game being taken away from me—not on my terms,” he said.
With full support from the Broncos’ coaching staff, medical team, and teammates, he suited up three days after learning he had cancer.
Swift Surgery and a Remarkable Comeback
Singleton underwent surgery to remove the tumor the day after the Las Vegas matchup. Thankfully, the procedure was less invasive than initially expected, and post-surgery scans showed the cancer hadn’t spread.
Just 23 days after the operation, he made a stunning return to the field.
In his comeback game against Washington, Singleton delivered a critical defensive play in the fourth quarter, helping force the game into overtime—where Denver secured another win.
After the victory, emotions finally broke through. Opponents, coaches, and teammates all approached him with support and encouragement, reinforcing that his journey had touched people across the league.
“It meant so much to me. It was bigger than football.”
Using His Story to Help Others
Singleton says he’s already heard from people who sought medical exams because of his experience. He wants men—especially young adults—to feel comfortable discussing their health and seeking help early.
He emphasizes that testicular cancer is often highly treatable when detected early, and his experience proves that diagnosis does not have to be devastating.
His message:
- Don’t ignore changes in your body
- Talk openly about health concerns
- Being vulnerable builds stronger connections
Broncos’ Fairytale Season: A Super Bowl Dream
The Broncos, now one of the NFL’s strongest teams, sit at an impressive 10-2. Their defense leads the league in sacks and is on pace to challenge the all-time record. Under head coach Sean Payton, Denver has developed a tough, resilient culture—an environment that supported Singleton through his most challenging month.
Singleton believes his experience has given him a new perspective and renewed motivation. With five games left, the Broncos aim to push through the playoffs and reach the Super Bowl at Levi’s Stadium—just as they did in 2015.
“I’m going to cherish every week like it could be my last. And hopefully, we’ll be lifting that Lombardi Trophy soon.”
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